Parameter Viewer

Document ID ca-ctdw-2016-02-12 Title Cyanobacterial Toxins in Drinking Water URL https://www.canada.ca/en/health-canada/programs/cyanobacterial-toxins-drinking-water/cyanobacterial-toxins-drinking-water.html Jurisdiction /ca Subdomain(s) Drinking water, Water quality standards, Treatment processes, Monitoring and analysis Language en Status completed Analyzed at 2026-03-17 14:23:41.637309+00:00 Relevance Public consultation on drinking water guidelines and treatment technologies.

Q Qualitative Requirements (109)

Req ID Category Intent Legal Status Name Subdomain(s) Context Conditions Confidence
#Q001reportinghealthrecommendedInfant formula alternate water source advicedrinking waterBecause of the increased exposure of infants relative to body weight, as a precautionary approach during a cyanobacterial bloom, or when microcystins are detected in finished water, drinking water authorities should consider informing the public in the affected area that an alternate suitable source of drinking water (such as bottled water) should be used to reconstitute infant formula.During a cyanobacterial bloom or when microcystins are detected in finished water.high
#Q002monitoringreportingrecommendedMicrocystin variants analysisdrinking waterAnalysis should be conducted for all of the measurable microcystin variants that are both dissolved in the water and bound within the cyanobacterial cells using a laboratory validated method.high
#Q003treatmenttreatmentrecommendedTreatment for intracellular and dissolved microcystinsdrinking waterSimilarly, water should be treated to remove both intracellular (cell-bound) and dissolved microcystins.high
#Q004administrativeoperationalrecommendedMonitoring and response strategy developmentdrinking waterResponsible authorities and water supply managers should develop an appropriate monitoring and response strategy for their systems.high
#Q005monitoringoperationalrecommendedRoutine monitoring for cyanobacteriadrinking waterDrinking water supplies known or suspected to be susceptible to blooms should be monitored routinely for the presence of cyanobacteria.When drinking water supplies are known or suspected to be susceptible to blooms.high
#Q006monitoringoperationalrecommendedVisual monitoring of source watersdrinking waterThe recommended approach is visual monitoring of source waters for evidence of increasing cyanobacterial cell density or bloom development, followed by increased vigilance and additional steps if such evidence is detected.high
#Q007monitoringoperationalrecommendedPeak season visual monitoringdrinking waterWater bodies that have exhibited blooms should be visually monitored during the peak season (usually late May to early October, but this may deviate depending on local conditions).During the peak season in water bodies that have exhibited blooms.high
#Q008monitoringreportingrecommendedSample collection during suspected bloomdrinking waterSamples should be collected for analysis if a bloom is detected or suspected by visual inspection, and may also be collected as part of routine surveillance.If a bloom is detected or suspected by visual inspection.high
#Q009monitoringreportingrecommendedSource water bloom sampling location and variabilitydrinking waterIn the source water, if a bloom develops, it should be sampled to establish the extent of its spread and the variability in the population. Sampling from a water body should be done as close to the inlet/shore and/or the bloom formation as possible.If a bloom develops in the source water.high
#Q010monitoringreportingrecommendedRaw water sampling prior to pretreatmentdrinking waterRaw water samples should be collected at the intake to the treatment plant prior to any pretreatment, including prechlorination or filtration to determine the concentration of microcystins entering the treatment plant.high
#Q011monitoringreportingrecommendedTreated water sampling locationdrinking waterTreated samples should be taken at the treated water tap of the treatment plant after the final treatment step.high
#Q012monitoringreportingrecommendedToxin analysis triggerdrinking waterToxin analysis should be performed on the raw and treated water supply if the responsible authority determines that the drinking water intake is vulnerable to contamination by a cyanobacterial bloom.If the responsible authority determines that the drinking water intake is vulnerable to contamination by a cyanobacterial bloom.high
#Q013monitoringreportingrecommendedTotal microcystins measurement requirementdrinking waterAlthough the guideline is based on the toxicity of microcystin-LR (MC-LR), it is important to measure total microcystins, which includes all of the measurable microcystin variants, not just MC-LR, that are free in the water as well as bound within cyanobacterial cells.high
#Q014monitoringreportingrecommendedRecommended analytical methods for microcystinsdrinking waterIn general, laboratory enzyme-linked immunosorbent assay (ELISA), protein phosphatase inhibition assays (PPIA) or a physicochemical method such as liquid chromatography with tandem mass spectrometry (LC-MS/MS) should be used to measure total microcystins in treated water.high
#Q015monitoringreportingrecommendedSecondary physicochemical analysis recommendationdrinking waterIt is recommended that when microcystins are detected in source or drinking water using ELISA or PPIA, a portion of subsequent samples should be analyzed using a physico-chemical method (i.e., LC-MS/MS) so that the predominant variants in a bloom can be identified and quantified and potential low level microcystin concentrations can be measured.When microcystins are detected in source or drinking water using ELISA or PPIA.high
#Q016reportingreportingrecommendedNotification of exceedancedrinking waterIf results for treated water exceed the proposed MAC, the sampling authority should follow standard protocol for notifying communities and other appropriate authorities and agencies.If results for treated water exceed the proposed MAC.high
#Q017reportinghealthrecommendedNotification of dialysis treatment providersdrinking waterDialysis treatment providers at all levels (e.g., large facilities/hospitals, small community facilities, mobile units, providers for independent/home dialysis) should also be notified, especially if it is a first-time occurrence for blooms on this supply.If results for treated water exceed the proposed MAC.high
#Q018corrective_actionoperationalguidanceCorrective actions and risk assessment initiationdrinking waterIf results for treated water exceed the proposed MAC, the responsible authorities may wish to: resample the treated water supply and perform additional toxin analysis; initiate risk assessment consultation and decision-making.If results for treated water exceed the proposed MAC.high
#Q019corrective_actionhealthguidanceActions following confirmation of exceedancedrinking waterIf results for the confirmation sample exceed the MAC, the responsible authorities may wish to: notify communities and other appropriate authorities; issue a do not consume advisory; consider treatment improvements, intake adjustments or use of an alternative supply as part of ongoing consultation and decision-making; communicate that lysing of the bloom by the addition of algicides may be harmful and that boiling is not effective in reducing or removing microcystins; continue monitoring the raw water and treated water supply.If results for the confirmation sample exceed the MAC.high
#Q020reportingreportingrecommendedCommunication of non-exceedance resultsdrinking waterIf results for the confirmation sample do not exceed the MAC, results should be sent to the communities and other appropriate authorities and agencies.If results for the confirmation sample do not exceed the MAC.high
#Q021monitoringoperationalrecommendedContinued visual monitoring post-confirmationdrinking waterAuthorities and water providers should continue to visually monitor the source water for intensification of the existing bloom or bloom recurrence if still in the season where cyanobacterial blooms could developIf still in the season where cyanobacterial blooms could develop.high
#Q022monitoringoperationalrecommendedRoutine monitoring for residential and private systemsdrinking waterSurface water drinking water supplies known or suspected to be susceptible to blooms should be monitored routinely for the presence of cyanobacteria. The recommended approach for residential scale and private supplies is for owners or authorities to visually monitor the source waters during the peak season for evidence of increasing cyanobacterial cell density or bloom development.For surface water drinking water supplies known or suspected to be susceptible to blooms.high
#Q023reportinghealthrecommendedConsultation on suspected contaminationdrinking waterOwners of residential scale and private drinking water systems who suspect that their water has been contaminated with cyanobacteria should consult their local health authority as to whether a concern exists and what actions should be taken.If owners suspect their water has been contaminated with cyanobacteria.high
#Q024corrective_actionhealthmandatoryCorrective action options for individual householdsdrinking waterIn cases where an individual household obtains its drinking water from a surface water supply where there is a cyanobacterial bloom present and microcystins may be present, consumers need to consider the best option for obtaining a safe drinking water supply.When an individual household obtains drinking water from a surface water supply where there is a cyanobacterial bloom present.high
#Q025administrativetreatmentrecommendedConsultation prior to residential treatment installationdrinking waterIt is recommended that a qualified person be consulted prior to selecting and installing a residential scale treatment system.high
#Q026monitoringreportingrecommendedLaboratory accreditation and QA/QC discussiondrinking watermicrocystin analyses should be conducted by an accredited laboratory and/or water utilities should discuss in detail the methodology and quality assurance/quality control (QA/QC) of the laboratory selected to conduct the analyses.high
#Q027monitoringreportingrecommendedPhysicochemical analysis of subsequent samplesdrinking waterWhen microcystins are detected in source or drinking water, a portion of subsequent samples should be analyzed using a physicochemical method (e.g., LC-MS/MS) so that the predominant variants in a bloom can be identified and quantified and potential low level microcystin concentrations can be measured.When microcystins are detected in source or drinking water.high
#Q028monitoringreportingrecommendedAnalysis for total microcystinsdrinking waterTherefore, it is important to note that analysis for microcystins should be for total microcystins, which should include all of the measurable microcystin variants, not only MC-LR, that are dissolved in the water as well as bound to or inside cyanobacterial cells.high
#Q029monitoringreportingrecommendedLaboratory instructions for sample handlingdrinking waterUtilities should obtain specific instructions from the laboratory on sample collection, preservation and shipping.high
#Q030monitoringreportingrecommendedAmber glass bottle sampling requirementdrinking waterIn general, samples for microcystin analysis should be collected in amber glass bottles as microcystins have been shown to sorb to polypropylene...high
#Q031monitoringreportingrecommendedMethod validation for sample preparationdrinking waterTherefore, it is important for responsible authorities to ensure that laboratories are validating the methods chosen for sample preparation.high
#Q032monitoringtreatmentrecommendedSeparate sampling for total and dissolved microcystinsdrinking waterIn this case, two samples should be taken, with one processed for total microcystin analysis and the other filtered in the laboratory or field and then analyzed for dissolved microcystins (extracellular).When utilities need an understanding of amounts present in both intracellular and dissolved forms.high
#Q033monitoringreportingrecommendedFiltration to minimize cell damagedrinking waterSamples should be carefully filtered to minimize cell damage so that the microcystin concentration in the filtrate is representative of the dissolved fraction.high
#Q034monitoringreportingrecommendedAppropriate extraction method usagedrinking waterGiven the variations in cell lysis and extraction efficiency discussed above, responsible authorities should ensure that the appropriate methods are being used in the laboratory depending on the type of sample, the analytical method selected and the microcystins being investigatedhigh
#Q035monitoringreportingmandatoryLaboratory recovery method validationdrinking waterIt is critical for laboratories to validate the methods chosen to ensure that adequate recovery of microcystins is achieved.high
#Q036monitoringreportingrecommendedOn-site analysis verificationdrinking waterIn cases where utilities choose to perform analyses at the treatment plant, it is recommended that the analyses be conducted by a well-trained technician or analyst and that duplicate samples be sent periodically to an accredited laboratory to confirm the on-site analyses.In cases where utilities choose to perform analyses at the treatment plant.high
#Q037monitoringreportingmandatoryAppropriate quencher addition checkdrinking waterThe potential for interferences varies depending on the type of ELISA, and therefore utilities need to check with the laboratories conducting their analyses to ensure that the appropriate quencher is being added to drinking water samples.When conducting ELISA analyses on drinking water samples containing quenchers.high
#Q038administrativereportingrecommendedUnderstanding of ELISA system limitationsdrinking waterAs many laboratories in Canada are using ELISA methods for the routine analysis of microcystins, it is important for responsible authorities to have an understanding of the cross-reactivity, sensitivity, matrix interferences and detection limits of the type of ELISA system being used so that the limitations of the analytical results can be considered in the decision-making process.high
#Q039monitoringreportingmandatoryField test kit lysing agent usagedrinking waterWhen using these field test kits, users need to purchase a lysing agent and release the intracellular microcystins in order to determine the level of total microcystins.When using field test kits that do not include a lysing agent.high
#Q040monitoringreportingrecommendedQuantitative analysis for compliancedrinking water...compliance testing or longer-term decision-making should be conducted using accurate quantitative analytical methods.For compliance testing or longer-term decision-making.high
#Q041monitoringreportingrecommendedCombined screening and physicochemical analysisdrinking waterTo ensure accurate quantification and characterization of microcystins, it is recommended that a screening method (ELISA, PPIA) be combined with a physicochemical method (HPLC-UV or LC-MS/MS).high
#Q042monitoringreportingrecommendedEnhanced sensitivity testing for low levelsdrinking waterWhen utilities want to determine if low levels (< 0.4 µg/L) of microcystins are present in treated drinking water, enhanced sensitivity ELISA kits or LC-MS/MS methods should be used for analysis.When utilities want to determine if low levels (< 0.4 µg/L) of microcystins are present in treated drinking water.high
#Q043monitoringreportingrecommendedRaw and treated water physicochemical analysisdrinking waterIn addition, a portion of raw and treated water samples should be analyzed using a physico-chemical method (LC-MS/MS or HPLC-PDA) so that an understanding of the types and amount of variants present in the bloom is obtained and treatment plant effectiveness can be more accurately predicted and/or assessed.high
#Q044administrativereportingrecommendedUnderstanding analytical methods and factorsdrinking waterIt is particularly important for responsible authorities to have an understanding of the methods being used by the laboratory selected for microcystin analysis and to discuss the factors that may affect the interpretation of the results.high
#Q045treatmenttreatmentrecommendedTreatment of both intracellular and dissolved toxinsdrinking waterIn most cases, there will be both intracellular and dissolved toxins present in the source water entering a treatment plant, and utilities should consider treatment of both formshigh
#Q046treatmenttreatmentrecommendedOptimization of coagulation/flocculationdrinking waterTherefore, it is recommended that the existing coagulation/flocculation processes be optimized before considering a change in coagulants during a cyanobacterial bloomBefore considering a change in coagulants during a cyanobacterial bloom.high
#Q047treatmentoperationalrecommendedIsolation of sludge and supernatantdrinking waterDuring a cyanobacterial bloom, sludge and sludge supernatant should be isolated from the water treatment plant.During a cyanobacterial bloom.high
#Q048treatmentoperationalrecommendedFilter-to-waste practicedrinking waterAdditionally, backwash water from the filters may contain cyanobacterial cells and/or dissolved microcystins; hence, filter-to-waste should be practised to prevent the reintroduction of cells and toxins into the treatment train.high
#Q049treatmentoperationalrecommendedFrequent filter backwashingdrinking waterFrequent backwashing has been recommended to minimize the risk of breakthrough of cells into filtered waterDuring periods of high algal concentrations.high
#Q050treatmenttreatmentrecommendedActivated carbon process testingdrinking waterWater treatment plants should conduct testing to determine the most effective activated carbon process for their water quality.high
#Q051treatmenttreatmentrecommendedGAC carbon testing prior to installationdrinking waterGiven the variability in adsorption of microcystins depending on the variant and carbon type, utilities should conduct testing to select the most effective carbon prior to installing GAC.Prior to installing GAC.high
#Q052treatmenttreatmentrecommendedPAC dose and contact time considerationdrinking water...a PAC dose of 20 mg/L and a contact time of at least 45 minutes should be considered for removal of most dissolved microcystins (with the exception of MC-LA).high
#Q053treatmenttreatmentrecommendedOxidant selection based on source waterdrinking water...selection of the most appropriate oxidant for microcystins should be based on the characteristics of each source waterhigh
#Q054treatmenttreatmentrecommendedChemical oxidation post-cell removaldrinking water...it is a general recommendation that chemical oxidation be conducted following the removal of cyanobacterial cells to help minimize the concentration of dissolved microcystinshigh
#Q055treatmenttreatmentrecommendedChlorination dose and contact time adjustmentsdrinking water...water suppliers should be aware of which microcystin variants are present in their water source, as variants are oxidized to a different degree, and oxidant doses and contact times may need to be adjusted accordingly.high
#Q056treatmenthealthmandatoryChlorine dioxide dose limit for DBP controldrinking waterIn addition, utilities need to limit the ClO2 dose applied to limit the chlorite and chlorate in the finished water. Chlorite and chlorate are not easily removed once formed, and their levels must be controlled by limiting the ClO2 dose in order to meet the guidelinesWhen using chlorine dioxide as an oxidant.high
#Q057treatmentaestheticrecommendedPermanganate dosage controldrinking waterTreatment plants considering potassium permanganate for oxidation of microcystins should be aware that permanganate can discolour water when it is present at concentrations in excess of 0.05 mg/L. Therefore, dosage control is important to avoid consumer complaintsWhen considering potassium permanganate for oxidation of microcystins.high
#Q058treatmenthealthrecommendedOzonation bromate formation assessmentdrinking waterUtilities should also be aware that the use of ozone may result in the formation of bromate and other DBPs. As such, characterization of the source water needs to be undertaken to ascertain the potential for bromate formationWhen using ozone for oxidation.high
#Q059treatmenthealthrecommendedOzone cyanobacterial control vs DBP formationdrinking waterThe authors recommended that utilities using ozone for oxidation of cyanobacterial cells consider the benefit of cyanobacterial control with the potential increased formation of chlorinated DBPs.When using ozone for oxidation of cyanobacterial cells.high
#Q060treatmenttreatmentmandatoryOptimization and monitoring of combined treatmentsdrinking waterUtilities need to ensure that the treatment processes in place have been optimized for removal of both cyanobacterial cells and dissolved microcystins and that the appropriate monitoring is being conducted to ensure that adequate removal is occurring at each step in the treatment process.high
#Q061monitoringreportingrecommendedAnalysis of treated water cell lysisdrinking water...it is important that analysis of treated water include cell lysis so that the total microcystin concentration is determined.high
#Q062treatmenttreatmentrecommendedFinal treatment barrier adjustmentdrinking waterIn addition, the final treatment barrier, such as oxidation, may need to be adjusted to account for the presence of intracellular microcystins (i.e., oxidation of cells and dissolved microcystins).If intracellular microcystins are present prior to final treatment barrier.high
#Q063treatmenthealthrecommendedResidential POE filtration installationdrinking waterThe first step should be the installation of a filtration system at the point of entry (POE) to the home to reduce the number of cyanobacterial cells that are present in water used for bathing and washing dishes.When using residential-scale treatment for cyanobacteria.high
#Q064treatmenttreatmentrecommendedPOE installation upstream of disinfectiondrinking waterThis POE filtration system should also be installed upstream of any disinfection that may already be present in the home treatment system (e.g., UV or chlorination).When installing residential POE filtration.high
#Q065treatmenthealthrecommendedResidential POU filtration installationdrinking waterThe final filtration step should be a filter system installed at the point of use (POU) of drinking water—for example, before the kitchen faucet. This POU filtration system should include an activated carbon filter followed by an RO filter.When using residential-scale treatment for cyanobacteria.high
#Q066administrativehealthrecommendedUse of certified residential treatment devicesdrinking waterConsumers should consider devices that have been certified under the standards that cover those technologies that are effective for microcystins (e.g., activated carbon, RO): NSF/ANSI Standard 58: Reverse Osmosis Drinking Water Treatment Systems; and NSF/ANSI Standard 53: Drinking Water Treatment Units—Health Effects.high
#Q067monitoringtreatmentrecommendedPre-installation water testingdrinking waterGenerally, before a treatment system is installed, the water should be tested to determine general water chemistry and to provide an estimate of the concentration of the contaminant to be removed.Before a residential treatment system is installed.high
#Q068monitoringreportingrecommendedPeriodic testing of home waterdrinking water...periodic testing should be conducted by an accredited laboratory on both the water entering the home and the finished water (at the POU) to verify that the treatment devices are effective.After installation of residential treatment devices.high
#Q069monitoringreportingrecommendedConsumer request for total microcystin analysisdrinking waterConsumers should request that the laboratory analyze for total microcystins, which includes both the microcystins that are within the cells of the cyanobacteria and the dissolved microcystins in the water.high
#Q070treatmentoperationalrecommendedMaintenance of residential treatment systemsdrinking water...consumers should verify its expected longevity and replace the medium and service the system when required, as per the manufacturer's recommendations.high
#Q071administrativeoperationalrecommendedEstablishment of an action plandrinking waterConsequently, an action plan should be established or updated prior to bloom season for systems using a surface water source that is or may be vulnerable to cyanobacterial blooms.Prior to bloom season for systems using a surface water source vulnerable to cyanobacterial blooms.high
#Q072administrativeoperationalrecommendedAction plan contentsdrinking waterThe action plan should lay out what to do in case a cyanobacterial bloom is visually detected in the water source. It should: describe the sampling strategy (parameters, frequency, timing, locations) to be followed for the duration of the bloom with respect to both routine sampling and resampling when microcystins are detected; identify the analytical laboratory or laboratories that can do microcystin analysis; ensure that agreement(s) and protocol(s) are in place with lab(s) for receiving and processing samples in a timely manner, and for communicating results from the lab to the appropriate contact people; outline individual responsibilities for how samples will be collected and delivered to the laboratory; specify the method(s) of microcystin detection/analysis that can be used; identify the appropriate contact people to receive the results from the lab and who they must notify if microcystins are detected; identify which authority or authorities are responsible to decide further notifications and actions; identify which authority will take the lead role in notifying communities and other appropriate agencies or authorities; set out a communications plan describing the circumstances and target groups for notifications, including when an advisory is issued or rescinded; include sample communications products, such as messages, Qs &As and press releases, to deal with different situations (e.g., microcystins level above guideline, microcystins detected below guideline level but still of concern for infants) and to provide clear guidance to the public; and identify any corrective actions (e.g., treatment adjustments) and the triggers for such actions.high
#Q073monitoringoperationalrecommendedPeak bloom season visual monitoringdrinking waterVisual monitoring of surface water sources should be conducted throughout the peak bloom season.Throughout the peak bloom season.high
#Q074monitoringreportingrecommendedFinished water samplingdrinking waterThe water provider or authorities should collect samples of finished water in the treatment plant, after the water has undergone the final treatment step and prior to its entry into the distribution system.high
#Q075monitoringoperationalrecommendedSample storage and transportdrinking waterSamples should be collected, stored and transported following instructions from the analytical laboratory.high
#Q076monitoringoperationalrecommendedSample handling conditionsdrinking waterIn general, samples should be clearly labelled and kept cool (not frozen) and in the dark (e.g., in coolers) after collection and during transport.high
#Q077monitoringreportingrecommendedAnalysis methods for samplesdrinking waterThe samples collected should be analysed using laboratory ELISA, PPIA or a physico-chemical method such as LC-MS/MS.high
#Q078monitoringreportingrecommendedSecondary LC-MS/MS analysisdrinking waterIf microcystins are detected using ELISA or PPIA, it is recommended that a portion of the samples also be analyzed using LC-MS/MS to identify and measure the individual microcystin variants which may be present.If microcystins are detected using ELISA or PPIA.high
#Q079monitoringoperationalrecommendedRaw water sampling for efficiency evaluationdrinking waterWater providers or utilities should consider also collecting raw water samples at this time to measure microcystins and cell counts and identify cyanobacteria species to help determine the efficiency of the treatment process.During a suspected bloom event.high
#Q080monitoringreportingrecommendedConfirmatory sampling for exceedancesdrinking waterAdditional sampling and analysis of the treated water should be conducted to confirm the concentration of total microcystins and identify follow up actions.If the concentration of total microcystins is above 1.5 µg/L.high
#Q081administrativeoperationalmandatoryAction plan reference on exceedancedrinking waterIf total microcystin levels are confirmed to be above the guideline of 1.5 µg/L, responsible authorities should refer to the facility-specific action plan developed as per section B.1.If total microcystin levels are confirmed to be above the guideline of 1.5 µg/L.high
#Q082reportinghealthrecommendedIssuance of Do Not Consume advisorydrinking waterThe lead authority should issue a “Do not consume” advisory and notify communities and other appropriate agencies or authorities.If total microcystin levels are confirmed to be above the guideline of 1.5 µg/L.high
#Q083corrective_actionhealthrecommendedAlternate drinking water source identificationdrinking waterIf possible, an alternate source of drinking water (such as bottled water) should be identified.If a 'Do not consume' advisory is issued.high
#Q084reportinghealthrecommendedNotification of dialysis providers on exceedancedrinking waterDialysis treatment providers or units in the community should also be notified.If total microcystin levels are confirmed to be above the guideline of 1.5 µg/L.high
#Q085monitoringreportingrecommendedResampling until compliancedrinking waterAuthorities and water providers should continue to resample and analyse the treated water until the concentration of total microcystins is confirmed to be at or below 1.5 µg/L.While total microcystins are confirmed to be above 1.5 µg/L.high
#Q086reportinghealthrecommendedInfant formula advice continuationdrinking waterHowever, authorities should continue to advise parents of infants of the approach to take when reconstituting infant formula, until microcystins are no longer detected in the treated water.Until microcystins are no longer detected in the treated water.high
#Q087monitoringoperationalmandatoryStaggered sampling for performance assessmentdrinking waterIf treatment performance is being assessed, then samples of raw and treated water need to be staggered to account for the residence time of water in the treatment plant.If treatment performance is being assessed.high
#Q088monitoringoperationalrecommendedSampling frequency factors considerationdrinking waterIn order to determine an appropriate sampling frequency, the following factors should be considered: past frequency of occurrence of blooms and cyanotoxins in the water source or nearby water bodies; characteristics of the water body (size, depth, current/flow, thermal stratification) and changes in these characteristics (e.g., prolonged periods of stagnation or decreased water levels); source water quality (nutrient levels, turbidity, clarity); seasonal and weather influences (inside/outside peak bloom season, temperature, prevailing wind strength and direction, rainfall) and changes to these influences; noted changes (increases/decreases) in monitoring program elements (cell counts, pigments, such as phycocyanin and chlorophyll-a, toxins); and adequacy of treatment and capacity of the treatment plant to deal with cyanotoxins.When determining an appropriate sampling frequency.high
#Q089administrativeoperationalrecommendedResponse discussion with authoritiesdrinking waterThe degree of response to the presence of total microcystins should be discussed with the appropriate authorities (e.g., for system ownership, regulation and health) and will depend on a risk-based assessment of the significance and extent of the problem, taking into account the history and variability of the quality of the raw water supply and the documented effectiveness of the treatment process.When microcystins are detected.high
#Q090reportinghealthguidancePrecautionary Do Not Consume advice for small systemsdrinking waterFor small systems that lack the necessary knowledge or treatment capabilities, the use of a do not consume advisory should be considered.For small systems lacking expertise or treatment capacity during bloom events.high
#Q091monitoringreportingmandatoryQuencher addition cautiondrinking waterCare must be taken when adding quenchers to samples as Froscio et al. (2010) found that sodium thiosulphate, sodium sulfite and taurine all affected analysis using ELISA, whereas ascorbic acid did not affect the assay results.When adding quenchers to samples prior to ELISA analysis.high
#Q092prohibitionoperationalrecommendedRecycling sludge supernatant prohibitiondrinking waterThe authors noted that recycling sludge supernatant (from wastewater ponds) to the head of the treatment plant should not be conducted during cyanobacterial blooms.During cyanobacterial blooms.high
#Q093treatmenttreatmentmandatoryMixing and flocculation optimizationdrinking waterSufficient mixing must be provided at the point of chemical addition to ensure rapid contact, and an appropriate mixing speed must be determined to optimize the flocculation process (Newcombe, 2009).During treatment plant operations for cell removal.high
#Q094treatmenttreatmentrecommendedRO system AC filter requirementdrinking waterRO systems should include an activated carbon filter within the unit, or a separate activated carbon device can be purchased and installed before (upstream of) the RO unit.When installing residential-scale RO systems for microcystin removal.high
#Q095monitoringreportingrecommendedTiming of sampling relative to bloom stagesdrinking waterIt is recommended that authorities analyze samples during, and after the collapse of, the bloom to better characterize the extent of the risk posed by the cyanobacteria (see Appendix B).During and after a bloom event.high
#Q096monitoringreportingmandatoryResampling for inconsistent resultsdrinking waterAs the results previous analyses (Boxes 6 and 8) are not consistent, another sample and analysis is needed to determine whether levels of total microcystins are a concern for the general population.When previous treated water samples for total microcystins show inconsistent results (e.g. one above and one below limit).high
#Q097treatmenttreatmentguidancePreoxidation adjustment during bloomsdrinking waterIn cases where preoxidation is practised, it may need to be discontinued during a cyanobacterial bloom, or adjustments to the oxidant type and doses may be needed to minimize cell rupture prior to filtration (Newcombe et al., 2015).During a cyanobacterial bloom for systems using preoxidation.high
#Q098monitoringoperationalguidanceSimultaneous raw and treated water samplingdrinking waterSamples of raw and treated supplies (if applicable) can be collected at the same time in order to be efficient.If applicable to improve efficiency.high
#Q099monitoringoperationalguidanceIn-plant sampling for performance assessmentdrinking waterSampling within the treatment plant after each treatment step (e.g., clarification, filtration) may also be needed to assess treatment plant performance.To assess treatment plant performance.high
#Q100monitoringoperationalguidanceVisual monitoring inside treatment facilitiesdrinking waterIt may be advisable to also conduct visual monitoring inside treatment facilities (e.g., clarifier, filter) as cyanobacteria may accumulate there even in the absence of a bloom in the source water.high
#Q101treatmenttreatmentmandatoryMulti-barrier approach requirementdrinking waterTo remove both intracellular and extracellular microcystins from drinking water, a multi-barrier approach is required, which may consist of conventional or membrane filtration for intracellular microcystin removal and granular activated carbon (GAC), powdered activated carbon (PAC), oxidation, biodegradation or small pore membrane processes for the removal of dissolved microcystins.When treatment is required to remove both intracellular and extracellular microcystins.high
#Q102administrativehealthmandatoryNatural Health Product licensing tolerance limitsotherIn Canada, licensing of natural health products that contain cyanobacteria must adhere to a finished product tolerance limit of 0.02 µg MC-LR/kg body weight (bw) per day or a raw material tolerance limit of 1 part per million (ppm) (Health Canada, 2015).For licensing of natural health products containing cyanobacteria in Canada.high
#Q103treatmentoperationalrecommendedAlgicide use discouragementdrinking waterhowever, the use of algicides to control blooms in drinking water source waters is discouraged.Regarding bloom control in drinking water source waters.high
#Q104treatmenthealthmandatorySaskatchewan microcystin standard compliance deadlinedrinking waterThe water treatment plants (WTPs) in Saskatchewan that are regulated by the WSA are required under the new regulations to meet the new drinking water standard for Microcystin-LR by July 1, 2020.For WTPs in Saskatchewan regulated by the Water Security Agency.high
#Q105administrativeoperationalrecommendedMonitoring strategy review during risk assessmentdrinking waterDuring the discussion process, possible treatment adjustments and strategy for continued monitoring of the treated water supply should be reviewed.During risk assessment consultation following a MAC exceedance.high
#Q106administrativeoperationalguidanceJurisdictional guidance acquisitiondrinking waterSpecific guidance related to the implementation of drinking water guidelines should be obtained from the appropriate drinking water authority in the affected jurisdictionWhen implementing drinking water guidelines.high
#Q107administrativeoperationalrecommendedMonitor training requirementdrinking waterAs accumulations of algae and pollen can be mistaken for cyanobacterial blooms, monitors should receive appropriate training to correctly identify blooms.For personnel responsible for visual monitoring of water sources.high
#Q108designtreatmentrecommendedResidential POE filter configurationdrinking waterThe filtration system should consist of a prefilter for removal of large particles (e.g., sand, sediment) followed by a filter with a smaller pore size for removal of cyanobacteria.When installing a point-of-entry (POE) filtration system for residential scale treatment.high
#Q109treatmenttreatmentrecommendedCoagulant determination via jar testingdrinking waterThe appropriate coagulant and coagulation pH should be determined through jar testing, and tests should be carried out on waters with high algal concentrations to maximize cell removal.During treatment plant operations for cell removal.high

P Quantitative Requirements (55)

Req ID Category Intent Legal Status Name Subdomain(s) Limit Type Limit Value Context Conditions Confidence
#P001chemicalhealthguidelinetotal microcystinsdrinking waterMAC0.0015 mg/LA seasonal maximum acceptable concentration of 0.0015 mg/L (1.5 µg/L) is proposed for total microcystins in drinking water.seasonalhigh
#P002chemicalhealthguidelinetotal microcystinsdrinking waterMAC1.5 µg/LA seasonal maximum acceptable concentration of 0.0015 mg/L (1.5 µg/L) is proposed for total microcystins in drinking water.seasonalhigh
#P003chemicalhealthmandatoryMC-LRotherrequirement0.02 µg MC-LR/kg body weight (bw) per dayIn Canada, licensing of natural health products that contain cyanobacteria must adhere to a finished product tolerance limit of 0.02 µg MC-LR/kg body weight (bw) per dayfinished product tolerance limithigh
#P004chemicalhealthmandatorycyanobacteriaotherrequirement1 ppmor a raw material tolerance limit of 1 part per million (ppm)raw material tolerance limit for natural health productshigh
#P005chemicalhealthguidelinetotal MC-LR (free plus cell bound)drinking waterunknown0.001 mg/LWHO (2003) established a provisional guideline value of 0.001 mg/L (1 µg/L) for total MC-LR (free plus cell bound).WHO provisional guideline valuehigh
#P006chemicalhealthguidelinetotal microcystinsdrinking waterunknown0.0013 mg/LThe Australian National Health and Medical Research Council established a guideline in 2001 for total microcystins in drinking water at 0.0013 mg/L (1.3 µg/L)expressed as MC-LR toxicity equivalentshigh
#P007chemicalhealthmandatorymicrocystinsdrinking waterMAC1 µg/LThe state of Ohio has established a maximum contaminant level of 1 µg/L for microcystinsOhio regulationhigh
#P008chemicalhealthmandatoryanatoxin-adrinking waterrequirement3 µg/Land the state of Oregon has established limits of 3 µg/L for anatoxin-aOregon regulationhigh
#P009chemicalhealthmandatorycylindrospermopsindrinking waterrequirement1 µg/L1 µg/L for cylindrospermopsinOregon regulationhigh
#P010chemicalhealthmandatorysaxitoxindrinking waterrequirement3 µg/Land 3 µg/L for saxitoxinOregon regulationhigh
#P011chemicalhealthguidelinemicrocystinsdrinking waterunknown1 µg/LNew Zealand has established provisional maximum acceptable values of 1 µg/L for microcystins (as MC-LRequiv)New Zealand regulationhigh
#P012chemicalhealthguidelinecylindrospermopsindrinking waterunknown1 µg/L1 µg/L for cylindrospermopsinNew Zealand regulationhigh
#P013chemicalhealthguidelinesaxitoxindrinking waterunknown3 µg/L3 µg/L for saxitoxin (as equivalents)New Zealand regulationhigh
#P014chemicalhealthguidelineanatoxin-adrinking waterunknown6 µg/L6 µg/L for anatoxin-aNew Zealand regulationhigh
#P015chemicalhealthguidelineanatoxin-a(s)drinking waterunknown1 µg/L1 µg/L for anatoxin-a(s)New Zealand regulationhigh
#P016chemicalhealthguidelinehomoanatoxin-adrinking waterunknown2 µg/L2 µg/L for homoanatoxin-aNew Zealand regulationhigh
#P017chemicalhealthguidelinenodularindrinking waterunknown1 µg/Land 1 µg/L for nodularinNew Zealand regulationhigh
#P018chemicalhealthguidelinemicrocystins (Oregon limit)drinking waterrequirement1-12 µg/Land the state of Oregon has established limits of 3 µg/L for anatoxin-a, 1 µg/L for cylindrospermopsin, 1–12 µg/L (indicated as “to be determined”) for microcystins and 3 µg/L for saxitoxinOregon regulationhigh
#P019chemicalhealthguidancecylindrospermopsin (Australia health advisory)drinking waterrequirement1 µg/LNon-regulatory health advisory levels of 1 μg/L and 3 μg/L were developed for cylindrospermopsin and saxitoxins, respectively.Australian non-regulatory health advisory levelhigh
#P020chemicalhealthguidancesaxitoxins (Australia health advisory)drinking waterrequirement3 µg/LNon-regulatory health advisory levels of 1 μg/L and 3 μg/L were developed for cylindrospermopsin and saxitoxins, respectively.Australian non-regulatory health advisory levelhigh
#P021chemicalhealthguidelinetotal microcystins (HBV)drinking waterrequirement2 µg/LThe HBV of 2.0 µg/L for total microcystins applies to both dissolved and intracellular toxins and is deemed to be protective of human healthcalculated Health-Based Valuehigh
#P022chemicalhealthguidancetotal microcystins (infant reference value)drinking waterrequirement0.4 µg/LApplying an infant (0-6 months) body weight of 7 kg and a consumption rate of 0.75 L/day, a reference value of 0.4 µg/L can be derived for the basis of recommending alternative sources of drinking water for bottle-fed infantsbottle-fed infants (0-6 months)high
#P023designoperationalguidanceintake depthdrinking waterOG>= 6 mAn intake located at least 6 m below the water surface is less likely to be affected by cyanobacteria present in the water body.to minimize impact of bloomsmedium
#P024operationaltreatmentguidancechlorine CT for microcystinsdrinking waterOG15-25 mg·min/LFor waters with a DOC of 5 mg/L and a microcystin concentration of 5 µg/L or less, CT values between 15 and 25 mg·min/L should be sufficient to achieve a treated water concentration below 1.0 µg/L.DOC <= 5 mg/L and microcystins <= 5 µg/Lmedium
#P025operationaltreatmentguidancePAC dose for microcystinsdrinking waterOG20 mg/LNewcombe et al. (2009) made a general recommendation that a PAC dose of 20 mg/L and a contact time of at least 45 minutes should be considered for removal of most dissolved microcystinsstandard recommendation for dissolved microcystin removalmedium
#P026operationaltreatmentguidancePAC contact time for microcystinsdrinking waterOG>= 45 minutesNewcombe et al. (2009) made a general recommendation that a PAC dose of 20 mg/L and a contact time of at least 45 minutes should be considered for removal of most dissolved microcystinsgeneral recommendation for most microcystinshigh
#P027physicalaestheticguidancePotassium permanganate discolouration thresholddrinking waterOG0.05 mg/Lpermanganate can discolour water when it is present at concentrations in excess of 0.05 mg/L. Therefore, dosage control is important to avoid consumer complaintsto avoid consumer complaints/discolourationhigh
#P028designtreatmentguidelineResidential filter absolute pore sizedrinking watertreatment_goal<= 1 µmBased on the size of cyanobacteria, a filter with an absolute pore size of 1 µm or less will likely remove most cellsresidential scale treatmenthigh
#P029operationaltreatmentguidancePAC dose for cylindrospermopsindrinking waterOG33 mg/LThe results demonstrated that to remove 5 µg/L of cylindrospermopsin to less than 1 µg/L, a PAC dose of 33 mg/L and a contact time of 30 minutes would be required.based on bench-scale and modelling studieshigh
#P030operationaltreatmentguidanceChlorine CT for cyanobacterial cell lysisdrinking waterOG100-296 mg·min/Lchlorine exposures between 100 and 296 mg·min/L were required to obtain 76% cell lysis (M. aeruginosa) and oxidation of released cell-bound MC-LR to below 1 µg/L.for 76% cell lysis of M. aeruginosahigh
#P031operationaltreatmentguidanceFree chlorine residual for microcystin oxidationdrinking waterOG0.5-1.5 mg/Lmicrocystins are efficiently oxidized if pH is maintained below 8, the chlorine dose is greater than 3 mg/L and 0.5–1.5 mg/L of free chlorine residual is present after 30 minutes of contact timepH < 8; contact time = 30 minhigh
#P032operationaltreatmentguidancePAC contact time for cylindrospermopsindrinking waterOG30 minutesThe results demonstrated that to remove 5 µg/L of cylindrospermopsin to less than 1 µg/L, a PAC dose of 33 mg/L and a contact time of 30 minutes would be required.to remove 5 µg/L cylindrospermopsin to < 1 µg/Lhigh
#P033operationaltreatmentguidanceCellular chlorine demand for M. aeruginosadrinking waterOG5.6 pg Cl2/cellThe authors also estimated that the cellular chlorine (as Cl2) demand of M. aeruginosa was 5.6 pg Cl2/cell, and this information could be used to adjust the chlorination dose of treatment plantsM. aeruginosa cells in waterhigh
#P034operationaltreatmentguidanceChlorine dose for microcystin oxidationdrinking waterOG> 3 mg/LSeveral studies have found that microcystins are efficiently oxidized if pH is maintained below 8, the chlorine dose is greater than 3 mg/L and 0.5–1.5 mg/L of free chlorine residual is present after 30 minutes of contact timefor efficient oxidationhigh
#P035operationaltreatmentguidancepH for microcystin oxidation with chlorinedrinking waterOG< 8 pH unitsSeveral studies have found that microcystins are efficiently oxidized if pH is maintained below 8, the chlorine dose is greater than 3 mg/L and 0.5–1.5 mg/L of free chlorine residual is present after 30 minutes of contact timefor efficient oxidationhigh
#P036chemicalhealthmandatorytotal microcystins (Brazil, France, Spain standard)drinking waterrequirement1 µg/LBrazil, France and Spain, have also established drinking water standards of 1 µg/L, however, for all microcystinsinternational standardshigh
#P037chemicalhealthmandatoryMC-LR (Czech Republic, Singapore, Uruguay standard)drinking waterrequirement1 µg/LDrinking water standards for MC-LR similar to that of WHO (2003) have been set by other international jurisdictions, including the Czech Republic, Singapore and Uruguayinternational standardshigh
#P038operationaltreatmentguidancechlorine CT for microcystinsdrinking waterOG15-25 mg·min/LFor waters with a DOC of 5 mg/L and a microcystin concentration of 5 µg/L or less, CT values between 15 and 25 mg·min/L should be sufficient to achieve a treated water concentration below 1.0 µg/L.DOC <= 5 mg/L and microcystins <= 5 µg/Lhigh
#P039operationaltreatmentguidancePAC dose for microcystinsdrinking waterOG20 mg/LNewcombe et al. (2009) made a general recommendation that a PAC dose of 20 mg/L and a contact time of at least 45 minutes should be considered for removal of most dissolved microcystinsstandard recommendation for dissolved microcystin removalhigh
#P040operationaltreatmentguidancePAC contact time for microcystinsdrinking waterOG>= 45 minutesNewcombe et al. (2009) made a general recommendation that a PAC dose of 20 mg/L and a contact time of at least 45 minutes should be considered for removal of most dissolved microcystinsgeneral recommendation for most microcystinshigh
#P041physicalaestheticguidancePotassium permanganate discolouration thresholddrinking waterOG0.05 mg/Lpermanganate can discolour water when it is present at concentrations in excess of 0.05 mg/L. Therefore, dosage control is important to avoid consumer complaintsto avoid consumer complaints/discolourationhigh
#P042designtreatmentguidelineResidential filter absolute pore sizedrinking watertreatment_goal<= 1 µmBased on the size of cyanobacteria, a filter with an absolute pore size of 1 µm or less will likely remove most cellsresidential scale treatmenthigh
#P043operationaltreatmentguidancePAC dose for cylindrospermopsindrinking waterOG33 mg/LThe results demonstrated that to remove 5 µg/L of cylindrospermopsin to less than 1 µg/L, a PAC dose of 33 mg/L and a contact time of 30 minutes would be required.based on bench-scale and modelling studieshigh
#P044operationaltreatmentguidanceChlorine CT for cyanobacterial cell lysisdrinking waterOG100-296 mg·min/Lchlorine exposures between 100 and 296 mg·min/L were required to obtain 76% cell lysis (M. aeruginosa) and oxidation of released cell-bound MC-LR to below 1 µg/L.for 76% cell lysis of M. aeruginosahigh
#P045operationaltreatmentguidanceFree chlorine residual for microcystin oxidationdrinking waterOG0.5-1.5 mg/Lmicrocystins are efficiently oxidized if pH is maintained below 8, the chlorine dose is greater than 3 mg/L and 0.5–1.5 mg/L of free chlorine residual is present after 30 minutes of contact timepH < 8; contact time = 30 minhigh
#P046operationaltreatmentguidancePAC contact time for cylindrospermopsindrinking waterOG30 minutesThe results demonstrated that to remove 5 µg/L of cylindrospermopsin to less than 1 µg/L, a PAC dose of 33 mg/L and a contact time of 30 minutes would be required.to remove 5 µg/L cylindrospermopsin to < 1 µg/Lhigh
#P047operationaltreatmentguidanceCellular chlorine demand for M. aeruginosadrinking waterOG5.6 pg Cl2/cellThe authors also estimated that the cellular chlorine (as Cl2) demand of M. aeruginosa was 5.6 pg Cl2/cell, and this information could be used to adjust the chlorination dose of treatment plantsM. aeruginosa cells in waterhigh
#P048operationaltreatmentguidanceChlorine dose for microcystin oxidationdrinking waterOG> 3 mg/LSeveral studies have found that microcystins are efficiently oxidized if pH is maintained below 8, the chlorine dose is greater than 3 mg/L and 0.5–1.5 mg/L of free chlorine residual is present after 30 minutes of contact timefor efficient oxidationhigh
#P049operationaltreatmentguidancepH for microcystin oxidation with chlorinedrinking waterOG< 8 pH unitsSeveral studies have found that microcystins are efficiently oxidized if pH is maintained below 8, the chlorine dose is greater than 3 mg/L and 0.5–1.5 mg/L of free chlorine residual is present after 30 minutes of contact timefor efficient oxidationhigh
#P050operationaloperationalguidanceVisual monitoring intervaldrinking waterrequirement1-2 weeksThe approach would require visual monitoring for evidence of bloom formation at regular intervals (one or two weeks).peak bloom seasonhigh
#P051operationaltreatmentguidelineISO 20179 Method MDLdrinking waterrequirement0.1 ng/µLThe standard [ISO 20179] requires that the method have an MDL of 0.1 ng/µL and an LOQ of 0.2 ng/µL.for method using solid phase extraction and HPLC/UVhigh
#P052operationaltreatmentguidelineISO 20179 Method LOQdrinking waterrequirement0.2 ng/µLThe standard [ISO 20179] requires that the method have an MDL of 0.1 ng/µL and an LOQ of 0.2 ng/µL.for method using solid phase extraction and HPLC/UVhigh
#P053operationaltreatmentguidelineEPA Method 544 Scan Ratedrinking waterrequirement>= 10 scansA minimum of 10 scans across the chromatographic peak is required to ensure adequate precision.during SPE and LC-MS/MS analysishigh
#P054operationaltreatmentguidanceMicrocystin screening thresholddrinking waterrequirement> 0.15 µg/LThe authors suggested that ELISA or PPIA could be used for the initial screening of samples, followed by HPLC-PDA or LC-MS/MS analysis on samples above the detection limit (approximately > 0.15 µg/L).threshold for switching from screening to physicochemical analysishigh
#P055designtreatmentguidanceEBCT for GAC microcystin removaldrinking waterOG> 10 minutesAlvarez et al. (2010) demonstrated that, in most cases, the EBCT for GAC filter adsorbers needs to be greater than 10 minutes to achieve adequate MC-LR removalwhen TOC concentrations between 1.5 and 5.1 mg/L are presenthigh

D Definitions (147)

Req ID Category Name Context Confidence
#D001extracellular microcystinsdissolved microcystins in the water outside of cyanobacterial cellshigh
#D002ALPalkaline phosphatasehigh
#D003ALS-PDCamyotrophic lateral sclerosis/parkinsonism–dementia complexhigh
#D004ALTalanine aminotransferasehigh
#D005ANSIAmerican National Standards Institutehigh
#D006AOPadvanced oxidation processhigh
#D007APCIatmospheric pressure chemical ionizationhigh
#D008ASTaspartate aminotransferasehigh
#D009BMAAβ-methylamino-L-alaninehigh
#D010bwbody weighthigh
#D011CIconfidence intervalhigh
#D012CTconcentration × timehigh
#D013CYPcytochrome P450high
#D014DAFdissolved air flotationhigh
#D015DBPdisinfection by-producthigh
#D016DMBAdimethylbenzanthracenehigh
#D017DMSOdimethyl sulphoxidehigh
#D018DNAdeoxyribonucleic acidhigh
#D019DOCdissolved organic carbonhigh
#D020EBCTempty bed contact timehigh
#D021ELISAenzyme-linked immunosorbent assayhigh
#D022EPAEnvironmental Protection Agency (U.S.)high
#D023equivequivalentshigh
#D024ERKextracellular signal-regulated protein kinasehigh
#D025ESIelectrospray ionizationhigh
#D026FSHfollicle stimulating hormonehigh
#D027GACgranular activated carbonhigh
#D028GCgas chromatographyhigh
#D029GDgestation dayhigh
#D030GGTgamma-glutamyltransferasehigh
#D031GnRHgonadotropin-releasing hormonehigh
#D032GSHglutathionehigh
#D033GSTglutathione S -transferasehigh
#D034HAAhaloacetic acidhigh
#D035HBVhealth-based valuehigh
#D036HPLChigh-performance liquid chromatographyhigh
#D037HUHazen unithigh
#D038IC 50median inhibitory concentrationhigh
#D039ISOInternational Organization for Standardizationhigh
#D040LCliquid chromatographyhigh
#D041LCATlecithin–cholesterol acyltransferasehigh
#D042LD 50median lethal dosehigh
#D043LDHlactate dehydrogenasehigh
#D044LDTDlaser diode thermal desorptionhigh
#D045LHluteinizing hormonehigh
#D046LOAELlowest-observed-adverse-effect levelhigh
#D047LOQlimit of quantificationhigh
#D048Mmoles per litre (molar)high
#D049MACmaximum acceptable concentrationhigh
#D050MALDImatrix-assisted laser desorption/ionizationhigh
#D051MAPKmitogen-activated protein kinasehigh
#D052MCmicrocystin variant (e.g., MC-LR, MC-LA, MC-YA, MC-RR, MC-YR)high
#D053MDLmethod detection limithigh
#D054MFmicrofiltrationhigh
#D055MMPmatrix metalloproteinasehigh
#D056MMPB2-methyl-3-methoxy-4-phenylbutyric acidhigh
#D057MRLminimum reporting levelhigh
#D058mRNAmessenger ribonucleic acidhigh
#D059MS/MStandem mass spectrometryhigh
#D060MTDmaximum tolerated dosehigh
#D061MWCOmolecular weight cut-offhigh
#D062NFnanofiltrationhigh
#D063NOAELno-observed-adverse-effect levelhigh
#D064NOMnatural organic matterhigh
#D065NSFNSF Internationalhigh
#D066NTUnephelometric turbidity unithigh
#D067OATPorganic anion-transporter polypeptidehigh
#D068ORodds ratiohigh
#D069PACpowdered activated carbonhigh
#D070PCRpolymerase chain reactionhigh
#D071PNDpostnatal dayhigh
#D072POEpoint of entryhigh
#D073POUpoint of usehigh
#D074PP1protein phosphatase 1high
#D075PP1cprotein phosphatase 1chigh
#D076PP2Aprotein phosphatase 2Ahigh
#D077PPIAprotein phosphatase inhibition assayhigh
#D078ppmpart per millionhigh
#D079QAquality assurancehigh
#D080QCquality controlhigh
#D081PDAphotodiode arrayhigh
#D082PQLpractical quantitation levelhigh
#D083RNAribonucleic acidhigh
#D084ROreverse osmosishigh
#D085ROSreactive oxygen specieshigh
#D086S99000 × g supernatant fraction from rat liver homogenatehigh
#D087SCCStandards Council of Canadahigh
#D088SPEsolid-phase extractionhigh
#D089SRRstandardized rate ratiohigh
#D090TDItolerable daily intakehigh
#D091TEFtoxicity equivalency factorhigh
#D092THMtrihalomethanehigh
#D093THPTamm-Horsfal proteinhigh
#D094TOCtotal organic carbonhigh
#D095TOFtime of flighthigh
#D096TPAO -tetradecanoylphorbol 13-acetatehigh
#D097UFultrafiltrationhigh
#D098UPLCultra-high-performance liquid chromatographyhigh
#D099UVultraviolethigh
#D100Visvisiblehigh
#D101cyanobacteriabacteria that have features in common with algae (they obtain energy through photosynthesis and are of similar size).high
#D102microcystinshepatotoxins that are inhibitors of the enzyme protein phosphatase, acting by disrupting the balance of phosphorylation and dephosphorylation in the structures that give liver cells their shape.high
#D103anatoxinsneurotoxins that interfere with the activity of the nerve transmitter acetylcholine.high
#D104saxitoxinsa group of related toxins that include saxitoxin, neosaxitoxin, the gonyautoxins and C-toxins which act by blocking sodium channels in nerves and muscle cells, preventing the transmission of electrical impulses.high
#D105alkaloidsa broad group of low to moderate molecular weight (< 1000 Da) compounds that contain ring structures and at least one carbon–nitrogen bond.high
#D106cylindrospermopsina toxic alkaloid with a molecular weight of approximately 400 Da and a tricyclic ring structure as one of its identifying features.high
#D107intracellular microcystinsmicrocystins stored within the cyanobacterial cells.high
#D108hepatotoxinsliver toxinshigh
#D109neurotoxinsnervous system toxinshigh
#D110dermatotoxinsskin toxinshigh
#D111irritant toxinstoxins that affect the skin and mucous membraneshigh
#D112ADDA groupa unique amino acid side chainhigh
#D113bloomsformed when conditions permit cyanobacteria to proliferate intensively to form a large populationhigh
#D114biovolume estimatescalculated by obtaining reference values for cell volume for each of the species present and multiplying these by the corresponding cell numbers present as determined from cell countshigh
#D115PQLpractical quantitation levelhigh
#D116LOQindicate the lowest concentration of an analyte that can be determined with an acceptable level of accuracy and precisionhigh
#D117MRLindicate the lowest concentration of an analyte that can be determined with an acceptable level of accuracy and precisionhigh
#D118MDLthe minimum concentration of an analyte that can be measured and reported with confidence that the concentration is greater than zerohigh
#D119sonicationthe use of ultrasonic sound waves to disrupt cyanobacterial cellshigh
#D120acanthocytesabnormal red blood cells characterized by a spiked external membranehigh
#D121akinetesresting stages that can provide protection for the organism in unfavourable temperatureshigh
#D122lag periods in microcystin biodegradationthe time between when microorganisms encounter the toxin and when breakdown beginshigh
#D123matrix effectsco-eluting substances and mobile-phase interferences, which can cause ion suppression or enhancement effectshigh
#D124Tamm-Horsfal protein (THP)the predominant mammalian protein in urinehigh
#D125Drinking Water Contaminant Candidate List 3a list of contaminants that are currently not subject to any proposed or promulgated national primary drinking water regulations, that are known or anticipated to occur in public water systems and that may require regulation under the Safe Drinking Water Act.high
#D126CDWFederal-Provincial-Territorial Committee on Drinking Waterhigh
#D127MDHAN-methyl-dehydroalaninehigh
#D128SRRstandardized rate ratiohigh
#D129MMP9matrix metalloproteinase 9high
#D130MMP2matrix metalloproteinase-2high
#D131PSPparalytic shellfish poisoninghigh
#D132DOMdissolved organic matterhigh
#D133THPTamm-Horsfal proteinhigh
#D134MC-LRmicrocystin-LRhigh
#D135total microcystinsincludes all of the measurable microcystin variants, not only MC-LR, that are dissolved in the water as well as bound to or inside cyanobacterial cells.high
#D136JNKc-Jun N-terminal protein kinasehigh
#D137MERISMedium Resolution Imaging Spectrometerhigh
#D138NOAANational Oceanic and Atmospheric Administrationhigh
#D139mcy genesthe genes responsible for the synthesis of microcystinshigh
#D140cyr genesthe genes responsible for the synthesis of cylindrospermopsinhigh
#D141ana genesthe genes responsible for the synthesis of anatoxin-ahigh
#D142sxt genesthe genes responsible for the synthesis of saxitoxinhigh
#D143normozoospermicnormal motile spermhigh
#D144asthenozoospermicsperm with reduced motilityhigh
#D145CGNcerebellar granule neuronshigh
#D146mcyD genesgenes that are part of the gene cluster coding for microcystin productionhigh
#D147LCMRLlowest concentration minimum reporting levelhigh